This is amino acids 17 to 26 fragment of p53, fluorescent labeled through an LC spacer. This peptide is the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that come into contact with the binding domain of Mdm-2. The tumor suppressor protein p53 is important in maintaining genome stability and in preventing cancer development, FITC (Abs/Em=493 nm/517 nm)..
Storage
-20°C
References
Yu, G. et al. PNAS 103, 1227 (2006), Wang, Y. et al. J. Biol. Chem. 281, 24803 (2006), Kanovsky, M. et al. PNAS 98, 12438 (2001).
Molecular Weight
1753.1
Sequence (One-Letter Code)
FITC-LC-ETFSDLWKLL-NH2
Sequence (Three-Letter Code)
FITC - LC - Glu - Thr - Phe - Ser - Asp - Leu - Trp - Lys - Leu - Leu - NH2
