This is amino acids 17 to 26 fragment of p53, fluorescent labeled through an LC spacer. This peptide is the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that come into contact with the binding domain of Mdm-2. The tumor suppressor protein p53 is important in maintaining genome stability and in preventing cancer development, FITC (Abs/Em=493 nm/517 nm)..
Yu, G. et al. PNAS 103, 1227 (2006), Wang, Y. et al. J. Biol. Chem. 281, 24803 (2006), Kanovsky, M. et al. PNAS 98, 12438 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
FITC - LC - Glu - Thr - Phe - Ser - Asp - Leu - Trp - Lys - Leu - Leu - NH2