This FCeRI g-chain ITAM-derived phosphorylated peptide is a substrate for protein tyrosine phosphatase 1 B (PTP1B). It is responsible for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases.
Yasuyuki, I. et al. J. Biochem.129, 861 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - pTyr - Thr - Gly - Leu - Ser - Thr - Arg - Asn - Gln - Glu - Thr - pTyr - Glu - Thr - Leu - NH2