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Peptides  >  Phosphopeptides  >>  PKC Substrate [RRGR-pT-GRGRRGIFR], Phosphorylated

Product Name PKC Substrate [RRGR - pT - GRGRRGIFR], Phosphorylated
RRGR - pT - GRGRRGIFR
Size 5 mg
Catalog # 60546-5
US$ $985
Purity % Peak Area By HPLC ≥ 95%
Description

The native peptide, RRGRTGRGRRGIFR (cat# 60542-1), is proven to be a highly selective substrate for Protein Kinase C (PKC). It is based on the amino acid sequence 1487-1500 of the non-structural protein 3 of Hepatitis C virus (HCV). Substitution of Tyr1499 in HCV by Phe makes the peptide substrate more effectively phosphorylated by rat brain PKC (Km = 5 M) and mouse epidermal cell extracts (Km = 25 nM) than other kinases such as tyrosine kinases or other serine/threonine kinases. It is very useful for assaying PKC activity in the presence of other kinases in tissues and crude cell extracts.

Storage -20C
References Ref: Borowski, P. et al. J. Biol. Chem. 274, 30722 (1999).
Molecular Weight 1780.9
Sequence
(One-Letter Code)
RRGR-pT-GRGRRGIFR
Sequence
(Three-Letter Code)
H - Arg - Arg - Gly - Arg - pThr - Gly - Arg - Gly - Arg - Arg - Gly - Ile - Phe - Arg - OH
     
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