Peptides  >  Amyloid Peptides  >  Islet Amyloid Polypeptides (IAPP)  >>  [NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22-27)

This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.