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Peptides  >  Amyloid Peptides  >  Beta-Amyloid (1-28) and Related Peptides  >>  Beta-Amyloid (1-28), Human

Product Name Beta - Amyloid (1 - 28), Human
DAEFRHDSGYEVHHQKLVFFAEDVGSNK
Size 0.5 mg
Catalog # AS-24231
US$ $105
Purity % Peak Area By HPLC ≥ 95%
Description

The three-dimensional solution structure of A (1-28) reveals the folding of the peptide to form a predominantly a-helical structure with a bend centered at residue 12 and the side chains of histidine-13 and lysine-16 in close proximity, residing on the same face of the helix. Their proximity may constitute a binding motif with the heparan sulfate proteoglycans. A (1-28) is highly hydrophilic and shares sequences with bA4, the major component of A. Its assembly is fibrillar, i.e., elongated in a single direction. Reports show that synthetic peptides A (1-40) and A (1-28) have significant effects on normal human plasma cholesterol esterification rate. Both peptides (at concentration of 1 ng/mL) inhibit plasma cholesterol esterification rate by 40-50% compared to the control value.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Kirshenbaum K. and V. Daggett, Biochem. 34, 7640 (1995); Talafous, J. et al. Biochem. 33, 7788 (1994).
Molecular Weight 3262.5
Sequence
(One-Letter Code)
DAEFRHDSGYEVHHQKLVFFAEDVGSNK
Sequence
(Three-Letter Code)
H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - OH
Product Citations Fukuyama, Y. et al. (2012). Alkylated dihydroxybenzoic acid as a MALDI matrix additive for hydrophobic peptide analysis. Anal Chem 84, 4237.
Libeu, CP. et al. (2011). Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides. J Alzheimer's Dis 25, 547.
Kanekiyo, T. et al. (2007). Lipocalin-type prostaglandin D synthase/β-trace is a major amyloid β-chaperone in human cerebrospinal fluid. PNAS 104, 6412.
Atwood, C. et al. (2004). Copper mediates dityrosine cross-linking of Alzheimer's amyloid-β. Biochem 43, 560.
     
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