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Peptides  >  Histones  >  Histone H3 Peptides  >>  [Lys(Ac)9]-Histone H3 (1-24), H3K9(Ac)

Product Name [Lys(Ac)9] - Histone H3 (1 - 24), H3K9(Ac)
ARTKQTAR - K(Ac) - STGGKAPRKQLATKA
Size 1 mg
Catalog # AS-64453
US$ $181
Purity % Peak Area By HPLC ≥ 95%
Description

This Histone 3 peptide is acetylated at lysine residue at 9th position. In a glioblastoma xenograft expressing a O6-methylguanine-DNA methyltransferase (MGMT), increased H3K9-ac was observed in correlation to histone acetylation and MGMT upregulation, thus demonstrating a mechanism driven by chromatin-mediated MGMT upregulation in potentially directing epigenetic therapies to influence the mechanisms of resistance development in glioblastomas.

Storage -20C
References Kitange GJ. et al. Clin Can Res. 18:4070 (2012)
Molecular Weight 2597
Sequence
(One-Letter Code)
ARTKQTAR-K(Ac)-STGGKAPRKQLATKA
Sequence
(Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg - Lys(Ac) - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Thr - Lys - Ala - OH
     
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