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Peptides  >  Histones  >  Histone H3 Peptides  >>  [Lys(Me2)36]-Histone H3 (21-44)-GK(Biotin), H3K36(Me2), biotin-labeled

Product Name [Lys(Me2)36] - Histone H3 (21 - 44) - GK(Biotin), H3K36(Me2), biotin - labeled
ATKAARKSAPATGGV - K(Me2) - KPHRYRPG - GK(Biotin)
Size 1 mg
Catalog # AS-64442-1
US$ $335
Purity % Peak Area By HPLC ≥ 95%
Description

This is a Histone 3 lysine 36 dimethylated peptide. This peptide has been shown to recruit histone deacetylase complex with nucleosomes and repress transcription. In addition, owing to its epigenetic repressive mark, it allows demethylation by a Jumonji C-domain family member, JMJD5 that functions as a transcription activator by inhibiting HDAC, and regulates cell cycle proliferation.

Storage -20C
References 1, Li B. et al. JBC. 284:7970-7976 (2009)
2, Hsia DA. et al. PNAS USA, 107(21):9671-9676 (2010).
Molecular Weight 2945.5
Sequence
(One-Letter Code)
ATKAARKSAPATGGV-K(Me2)-KPHRYRPG-GK(Biotin)
Sequence
(Three-Letter Code)
H - Ala - Thr - Lys - Ala - Ala - Arg - Lys - Ser - Ala - Pro - Ala - Thr - Gly - Gly - Val - Lys(Me2) - Lys - Pro - His - Arg - Tyr - Arg - Pro - Gly - Gly - Lys(Biotin) - OH
     
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