This peptide, a double cyclic peptide, binds preferentially to integrins at sites of tumor angiogenesis and inflammed synovium in-vivo, and can be internalized into targeted cells.
Ref: Curnis, F. et al. Cancer Res. 64, 565 (2004); Su, Z. et al. Bioconjug. Chem. 13, 561 (2002); Gerlag, M. et al. Arthritis Res. 3, 357 (2001); Ellerby, H. et al. Nature Med. 5, 1032 (1999);
Molecular Weight
1145.3
Sequence (One-Letter Code)
ACDCRGDCFCG (Disulfide bridge: 2-10 and 4-8)
Sequence (Three-Letter Code)
H - Ala - Cys - Asp - Cys - Arg - Gly - Asp - Cys - Phe - Cys - Gly - OH (Disulfide bridge: 2 - 10 and 4 - 8)
Datasheet
