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Peptides  >  Cell Permeable Peptides (CPP) / Drug Delivery Peptides  >>  Tat-GluR23Y

Product Name Tat - GluR23Y
YGRKKRRQRRRYKEGYNVYG
Size 1 mg
Catalog # 64429
US$ $110
Description

The synthetic peptide (Tat-Glur23Y) contains tyrosine residues that blocks phosphorylation of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis. Previous research shows that Tat-Glur23Y blocks regulated AMPA and thereby prevents long-term depression (LTD) in structures such as the nucleus accumbens and dorsal hippocampus.

Storage -20C
References Dalton, G. et al. Neuropsychopharma. 33, 2416 (2008); Kim, J. et al. PNAS 104, 20955 (2007).
Molecular Weight 2634
Sequence
(One-Letter Code)
YGRKKRRQRRRYKEGYNVYG
Sequence
(Three-Letter Code)
H - Tyr - Gly - Arg - Lys - Lys - Arg - Arg - Gln - Arg - Arg - Arg - Tyr - Lys - Glu - Gly - Tyr - Asn - Val - Tyr - Gly - OH
Product Citations Pauli, WM. et al. (2012). Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior. Learn Mem 19, 307.
Li, Y. et al. (2011). Inhibition of PKMζ in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci 31, 5436.
     
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