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Peptides  >  Viral Peptides  >>  Plasmodium falciparum Plasmodium falciparum Circumsporozoite Protein, (6NANP) PfCSP

Product Name Plasmodium falciparum Plasmodium falciparum Circumsporozoite Protein, (6NANP) PfCSP
NANPNANPNANPNANPNANPNANPC
Size 1 mg
Catalog # 64434
US$ $181
Description

The P. falciparum circumsporozoite protein (PfCSP) is the most abundant antigen expressed on the surface of P. falciparum sporozoites. This pre-erythrocytic antigen contains a stretch of 6 highly conserved, immunodominant tetrapeptide repeats (NANP) in the middle, while its N- and C-terminal regions contain two crucial protective regions termed RI and RII-plus, respectively. Both play key roles during parasite invasion. PfCSP has been the main target antigen in the development of preerythrocytic malaria vaccines, including subunit proteins with adjuvants or attenuated viral platforms. Studies show that high titers of antibodies directed to PfCSP are believed to interrupt the invasion of hepatocytes by blood-borne sporozoites, thereby abrogating the development of blood-stage malaria.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Zhang, Q. et al. Appl. Microbio. Biotech. 10, 1294 (2007).
Molecular Weight 2499.6
Sequence
(One-Letter Code)
NANPNANPNANPNANPNANPNANPC
Sequence
(Three-Letter Code)
H - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Cys - OH
     
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