4N1K is a cell-binding domain adhesive peptide. It has been identified as an IAP agonist. Integrin-associated protein (IAP) is important in host defense where it is required for integrin-dependent functions of polymorphonuclear leukocytes. IAP also appears to be important in modulating integrin function in other cells and in signal transduction upon ligand binding by certain integrins with which it associates.
Chung, J. et al. J Biol Chem272, 14740 (1997).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Lys - Arg - Phe - Tyr - Val - Val - Met - Trp - Lys - Lys - OH