This peptide sequence is found in residues 25 to 33 of the mouse self/tumor antigen glycoprotein (mgp100). This fragment is a H-2Db–restricted epitope recognized by CD8+ T cells. Mgp100 is an enzyme normally involved in pigment synthesis, and the epitope fragment is typically expressed in both normal melanocytes and melanoma cells.
Finkelstein, S. et al. J Leukoc Biol76, 333 (2004); Hosoi, A. et al. Cancer Res68, 3941 (2008); Overwijk, WW. et al. J Exp Med188, 277 (1998).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Glu - Gly - Ser - Arg - Asn - Gln - Asp - Trp - Leu - OH