Temporin L is a hydrophobic peptide amide derived from the frog Rana temporaria. This peptide penetrates the hydrophobic core of the cell membrane to penetrate and disrupt the lipid bilayer. Temporin L enhances Temporin A and Temporin B activity by preventing their oligomerization to Lipopolysaccharide (LPS), allowing them to bypass LPS and access the cytoplasmic membrane. This peptide is active against Gram-positive and Gram-negative bacteria, including B. megaterium and E. coli.
Rosenfeld, Y. et al. J Biol Chem281, 28565 (2006); Simmaco, M. et al. Eur J Biochem 242, 788 (1996); Zhao, H. et al. J Biol Chem 277, 25170 (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Phe - Val - Gln - Trp - Phe - Ser - Lys - Phe - Leu - Gly - Arg - Ile - Leu - NH2