This peptide is tumor suppressor protein, p53 (368-393). There is a biotinylated lyine followed by a GG linker at the N-terminal and an acetylated lysine at lysine 373. Activation of the p53 protein results in the transcription of antiproliferative proteins and induction of apoptosis. The p53 tumor suppressor is a principal mediator of growth arrest, senescence, and apoptosis in response to a broad array of cellular damage.
Kanovsky, M. et al. Proc Natl Acad Sci98, 12438 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Biotin - Lys - Gly - Gly - His - Leu - Lys - Ser - Lys - Lys(Ac) - Gly - Gln - Ser - Thr - Ser - Arg - His - Lys - Lys - Leu - Met - Phe - Lys - Thr - Glu - Gly - Pro - Asp - Ser - Asp - NH2