This FRET substrate peptide for Plasmepsin V (PMV) is derived from the conserved Plasmodium Export Element (PEXEL) motif of Histidine-Rich Protein II (HRPII). PMV is an ER aspartic protease that recognizes and cleaves the RXL sequence within the PEXEL motif of proteins exported by human malaria parasite Plasmodium falciparum, allowing them to translocate into host erythrocytes.
Russo, I. et al. Nature463, 632 (2010).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Dabcyl - Leu - Asn - Lys - Arg - Leu - Leu - His - Glu - Thr - Gln - EDANS