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Peptides  >  Amyloid Peptides  >  Other Amyloid Related Peptides  >>  Nβ25; Notch-1 Aβ-like Peptide

Product Name Nβ25; Notch - 1 Aβ - like Peptide
VKSEPVEPPLPSQLHLMYVAAAAFV
Size 1 mg
Catalog # AS-64880
US$ $181
Purity % Peak Area By HPLC ≥ 95%
Description

This 25-mer Notch-1 Aβ-like peptide is secreted during the Notch signaling pathway. Presenilin (PS)-dependent intramembrane proteolysis cleaves the Notch receptor at multiple sites, resulting in the release of Nβ21 and C-terminally elongated Nβ25, in a process similar to the production of Alzheimer disease-associated β-Amyloid during regulated intramembrane proteolysis (RIP).

Storage -20C
References Okochi, M. et al. J Biol Chem 281, 7890 (2006).
Molecular Weight 2694.2
Sequence
(One-Letter Code)
VKSEPVEPPLPSQLHLMYVAAAAFV
Sequence
(Three-Letter Code)
H - Val - Lys - Ser - Glu - Pro - Val - Glu - Pro - Pro - Leu - Pro - Ser - Gln - Leu - His - Leu - Met - Tyr - Val - Ala - Ala - Ala - Ala - Phe - Val - OH
     
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