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Peptides  >  Enzyme Substrates and Inhibitors  >>  NP-M2tide

Product Name NP - M2tide
GGAVDDDYAQFANGG
Size 1 mg
Catalog # 64681
US$ $83
Purity % Peak Area By HPLC ≥ 95%
Description

This 15-mer peptide is derived from NP-M2tide, a peptide that is able to bind to human M2 isoform of pyruvate kinase (PKM2). PKM2 is a phosphotyrosine-binding protein, that once bound to phosphotyrosine peptides, will release fructose-1,6-biphosphate that will block the enzymatic activity of PKM2. This event veers glucose metabolites from energy production to anabolic processes. PKM2 is also crucial for rapid cancer cell growth.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Christofk, H., et al. Nature, 452, 181 (2008).
Molecular Weight 1456.5
Sequence
(One-Letter Code)
GGAVDDDYAQFANGG
Sequence
(Three-Letter Code)
H - Gly - Gly - Ala - Val - Asp - Asp - Asp - Tyr - Ala - Gln - Phe - Ala - Asn - Gly - Gly - OH
     
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