This 21-mer Notch-1 Aβ-like peptide is secreted during the Notch signaling pathway. Presenilin (PS)-dependent intramembrane proteolysis cleaves the Notch receptor at multiple sites, resulting in the release of Nβ21 and C-terminally elongated Nβ25, in a process similar to the production of Alzheimer disease-associated Aβ during regulated intramembrane proteolysis (RIP).
Okochi, M. et al. J Biol Chem281, 7890 (2006).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Val - Lys - Ser - Glu - Pro - Val - Glu - Pro - Pro - Leu - Pro - Ser - Gln - Leu - His - Leu - Met - Tyr - Val - Ala - Ala - OH