This antimicrobial peptide is designated as NRC-13, a variant of Pleurocidin isolated from the American plaice. The sequence of NRC-3 is derived based on conserved flanking regions of Pleurocidin: an N-terminal signal peptide and a C-terminal acidic peptide. NRC-13 is effective against many Gram-positive and Gram-negative pathogens, and highly effective against P. aeruginosa.
Patrzykat, A. et al. Antimicrob Agents Chemother47, 2464 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Trp - Arg - Thr - Leu - Leu - Lys - Lys - Ala - Glu - Val - Lys - Thr - Val - Gly - Lys - Leu - Ala - Leu - Lys - His - Tyr - Leu - NH2