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Peptides  >  Histones  >  Histone H3 Peptides  >>  [pThr11]-Histone H3(1-21)-GGK(Biotin), H3pT11, biotin-labeled

Product Name [pThr11] - Histone H3(1 - 21) - GGK(Biotin), H3pT11, biotin - labeled
ARTKQTARKS - pT - GGKAPRKQLAGG - K(Biotin) - NH2
Size 1 mg
Catalog # 64973-1
US$ $325
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is histone H3 amino acid residues 1 to 21. It is phosphorylated at Thr-11 with a C-terminal GG linker, followed by a biotinylated lysine. The modification of Thr-11 via phosphorylation is processed by a number of enzymes, including protein kinase C-related kinase 1 (PRK1) and Serine/threonine-protein kinase Chk1. This has many important functions, such as the establishment of a novel chromatin marker for transcriptional regulation, and the regulation of DNA-damage induced transcriptional repression. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Storage -20C
References Metzger, E. et al. Nat Cell Biol 10, 53 (2010); Shimada, M. et al. Cell 132, 221 (2008).
Molecular Weight 2802.2
Sequence
(One-Letter Code)
ARTKQTARKS-pT-GGKAPRKQLAGG-K(Biotin)-NH2
Sequence
(Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg - Lys - Ser - pThr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Gly - Gly - Lys(Biotin) - NH2
     
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