This peptide is Histone H3 (21-44). It is acetylated at lysine 36 with a C-terminal G linker followed by a biotinylated lysine. The acetylation of histone H3 at lysine (K) 36 is highly conserved in mammals and is mainly localized to the promoters of RNA polymerase II-transcribed genes. The transition between the acetylation and methylation of K36 acts as an “acetyl/methyl switch”, controlling chromatin function along transcription units. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Morris, S. et al. J Biol Chem282, 7632.
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Thr - Lys - Ala - Ala - Arg - Lys - Ser - Ala - Pro - Ala - Thr - Gly - Gly - Val - Lys(Ac) - Lys - Pro - His - Arg - Tyr - Arg - Pro - Gly - Gly - Lys(Biotin) - OH