This peptide is a fusion of A208, derived from murine laminin a1, and the active site of fibronectin (GRGDS), with a glycine spacer. This peptide forms amyloid-like fibrils and promotes formation of actin stress fibers that mediate fibroblast cell attachment, offering it potential as a bioadhesive for tissue regeneration and engineering. FN-A208 interacts with IKVAV receptors and integrins. Its activity is disrupted by the presence of EDTA.
Storage
-20°C
References
Ohga, Y. et al. Biomater.30, 6731 (2009). Kasai, S. et al. Biopolymers Pept. Sci.76, 27 (2004).
Molecular Weight
1716.9
Sequence (One-Letter Code)
GRGDSGAASIKVAVSADR
Sequence (Three-Letter Code)
H - Gly - Arg - Gly - Asp - Ser - Gly - Ala - Ala - Ser - Ile - Lys - Val - Ala - Val - Ser - Ala - Asp - Arg - OH
