This is amino acid residues 16-37 of murine myelin oligodendrocyte basic protein (MOBP), a major component of CNS myelin which may play a role in the pathogenesis of multiple sclerosis. MOBP16-37 is the major encephalitogenic epitope for SJL/J mice and causes EAE.
Kerlero de Rosbo, N. et al. J Immunol173, 1426 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gln - Lys - Phe - Ser - Glu - His - Phe - Ser - Ile - His - Cys - Cys - Pro - Pro - Phe - Thr - Phe - Leu - Asn - Ser - Lys - Arg - OH