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Peptides  >  Histones  >  Histone H4 Peptides  >>  [Lys(Ac)16, Lys(Me1)20]-Histone H4 (1-25)-GSGSK(Biotin)

Product Name [Lys(Ac)16, Lys(Me1)20] - Histone H4 (1 - 25) - GSGSK(Biotin)
SGRGKGGKGLGKGGA - K(Ac) - RHR - K(Me1) - VLRDNGSGS - K(Biotin)
Size 1 mg
Catalog # 65210-1
US$ $335
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is histone H4 (1-25) with acetylation at Lys16 and monomethylation at Lys20, followed by a C-terminal GSGS linker and a biotinylated lysine. Lys16 is generally the first site of acetylation on histone H4. Monomethylation at Lys20 of H4 is catalyzed by PR-Set7 and concentrated in the nuclear periphery and heterochromatin of the inactive female X chromosome in vivo. Monomethylation of histone H4 at Lys20 is associated with transcriptional silent chromatin in higher eukaryotes. These two histone modifications are typically inversely correlated during the cell cycle. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Storage -20C
References Rice, J. et al. Gene Dev 16, 2225 (2002); Sims, J. et al. J Biol Chem 281, 12760 (2006).
Molecular Weight 3288.8
Sequence
(One-Letter Code)
SGRGKGGKGLGKGGA-K(Ac)-RHR-K(Me1)-VLRDNGSGS-K(Biotin)
Sequence
(Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys(Ac) - Arg - His - Arg - Lys(Me1) - Val - Leu - Arg - Asp - Asn - Gly - Ser - Gly - Ser - Lys(Biotin) - OH
     
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