This peptide is beta-amyloid (1-38) with phenylalanine and isoleucine universally labeled with 13C. Ab is found in amyloid deposits of Alzheimer’s patients and is implicated in the pathogenesis of this disease.
H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - *Phe - *Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - **Ile - **Ile - Gly - Leu - Met - Val - Gly - Gly - OH *Phe(U - 13C9); **Ile(U - 13C6)