This peptide is beta-amyloid (1-40) with leucine universally labeled with 13C. Ab is found in amyloid deposits of patients with Alzheimer’s and is implicated in the pathogenesis of this disease.
H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - *Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - *Leu - Met - Val - Gly - Gly - Val - Val - OH *Leu(U - 13C6)