This peptide is derived from apolipoprotein E4. Apolipoprotein is a plasma protein present in various organs, such as the spleen, kidney, liver, and brain that binds low-density lipoprotein receptors and participates in cholesterol transport and redistribution. Apoliprotein E also functions in peripheral nerve injury and regeneration, immunoregulation, and regulation of cell growth and differentiation. Apolipoprotein E4 has been implicated in sporadic and late onset Alzheimer’s disease.
Candiano, G. et al, Electrophoresis22, 1819 (2001); Poirier, J. et al. Proc Natl Acad Sci92, 12260 (1995); Mahley, RW. Science240, 622 (1988).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Glu - Leu - Glu - Glu - Gln - Leu - Thr - Pro - Val - Ala - Glu - Glu - Thr - Arg - OH