This peptide is a hyaluronan-binding peptide biotinylated through a C-terminal GGGSK linker. Hyaluronan (HA) is a nonsulfated glycosaminoglycan expressed in the extracellular matrix and on cell surfaces. HA plays a role in fertilization, embryonic development, wound healing, angiogenesis, leukocyte trafficking to inflamed tissues, and cancer metastasis. This peptide has been shown to block HA binding to CD44 receptors and inhibit T cell proliferation.
Mahaffey, C. and ME Mummert. J Immunol179, 8191 (2007); Mummert, M. et al. J Exp Med192, 769 (2000).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Ala - His - Trp - Gln - Phe - Asn - Ala - Leu - Thr - Val - Arg - Gly - Gly - Gly - Ser - Lys(Biotin) - OH