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Assay Kits  >  DDPIV Assay Kits  >>  SensoLyte® Rh110 DPPIV Assay Kit *Fluorimetric*

Product Name SensoLyte® Rh110 DPPIV Assay Kit *Fluorimetric*
Size 1 kit
Catalog # 72196
US$ $325
Description

DPPIV is a widely distributed serine protease that cleaves two amino acids from small peptides containing alanine or proline in the second position of the N-terminus of the peptide. DPPIV activity is especially critical for inactivation of GLP-1, a potent antihyperglycemic hormone, inducing glucose-dependent stimulation of insulin secretion. DPPIV inhibitors provide a potent treatment for type 2 diabetes prolonging the activity of GLP-1 and improving insulin secretion and blood glucose control regulation. The SensoLyte® Rh110 DPPIV Assay Kit provides a convenient method for high throughput screening of DPPIV inhibitors and for continuous assay of DPPIV activity utilizing a fluorogenic peptide. Upon enzyme cleavage, the peptide releases the Rh110 fluorophore with bright green fluorescence that can be detected at Ex/Em=490/520 nm. The longer-wavelength spectra and higher extinction coefficient of the Rh110 provide greater sensitivity and less interference from reaction components. Kit size: 100 assays.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
     
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