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Assay Kits  >  DDPIV Assay Kits  >>  SensoLyte® AMC DPPIV Assay Kit *Fluorimetric*

Product Name SensoLyte® AMC DPPIV Assay Kit *Fluorimetric*
Size 1 kit
Catalog # AS-72197
US$ $269
Description

DPPIV is a widely distributed serine protease that cleaves two amino acids from small peptides containing alanine or proline in the second position of the N-terminus of the peptide. DPPIV activity is especially critical for inactivation of GLP-1, a potent antihyperglycemic hormone, inducing glucose-dependent stimulation of insulin secretion. DPPIV inhibitors provide a potent treatment for type 2 diabetes prolonging the activity of GLP-1 and improving insulin secretion and blood glucose control regulation.

The SensoLyte® AMC DPPIV Assay Kit provides a convenient method for high throughput screening (HTS) of DPPIV inhibitors and for continuous assay of DPPIV activity using a fluorogenic substrate that has a high reactivity and low background. DPPIV cleaves the substrate resulting in release of AMC (7-amino-4-methylcoumarin) fluorophore. Fluorescence can be monitored at excitation /emission= 354/442 nm. This kit can be used for high throughput screening of DPPIV inhibitors.

Kit size: 100 assays.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
     
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