This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with acetylation at Lys373 and additional KGW residues on its N-terminus. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo.
Kubbutat, M. et al. Lett Nature387, 299 (1997); Li, M. et al. J Biol Chem277, 50607 (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Biotin - Lys - Gly - Trp - His - Leu - Lys - Ser - Lys - Lys(Ac) - Gly - Gln - Ser - Thr - Ser - Arg - His - Lys - Lys - Leu - Met - Phe - Lys - Thr - Glu - Gly - Pro - Asp - Ser - Asp - NH2