This peptide is histone H2A (1-22) deiminated at Arg3, followed by a C-terminal GK with biotinylation on the side chain of Lys. Deimination of Arg3 to Cit is catalyzed by peptidylarginine deiminase (PADI)-4. This regulates arginine methylation and mediates gene expression. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Saiki, M. et al. Protein Pept Lett16, 1012 (2009); Hagiawara, T. et al. Biochem44, 5827 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Cit - Gly - Lys - Gln - Gly - Gly - Lys - Ala - Arg - Ala - Lys - Ala - Lys - Ser - Arg - Ser - Ser - Arg - Ala - Gly - Gly - Gly - Lys(Biotin) - OH