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Peptides  >  Histones  >  Histone H3 Peptides  >>  [Arg(Me2s)2, Lys(Ac)4]-Histone H3 (1-21)-GGK(Biotin)

Product Name [Arg(Me2s)2, Lys(Ac)4] - Histone H3 (1 - 21) - GGK(Biotin)
A - R(Me2s) - T - K(Ac) - QTARKSTGGKAPRKQLAGG - K(Biotin)
Size 1 mg
Catalog # 65267-1
US$ $435
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is histone H3 (1-21) with symmetrical dimethylation at Arg2 and acetylation at Lys4, followed by a C-terminal GGK with biotinylation on the side chain of Lys. Dimethylation of the guanidinium group of Arg2 is associated with transcriptional silencing. Lys4 acetylation acts as a chromodomain switch by weakening the interaction between Chp1 and the H3K9 methylated tail, thus facilitating binding of HP1 proteins. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Storage -20C
References Xhemalce, B. and T. Kouzarides Gene Dev 24, 647 (2010); Musselman, CA and TG. Kutateladze Mol Interv 9, 314 (2010); Kirmizis, A. et al. Nat Struct Mol Biol 16, 449 (2009); Garcia, B. et al. J Biol Chem 282, 7641 (2007).
Molecular Weight 2793.3
Sequence
(One-Letter Code)
A-R(Me2s)-T-K(Ac)-QTARKSTGGKAPRKQLAGG-K(Biotin)
Sequence
(Three-Letter Code)
H - Ala - Arg(Me2s) - Thr - Lys(Ac) - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Gly - Gly - Lys(Biotin) - OH
     
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