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Peptides  >  Histones  >  Histone H3 Peptides  >>  [Arg(Me2s)2, Lys(Me2)4]-Histone H3 (1-21)-GGK(Biotin)

Product Name [Arg(Me2s)2, Lys(Me2)4] - Histone H3 (1 - 21) - GGK(Biotin)
A - R(Me2s) - T - K(Me2) - QTARKSTGGKAPRKQLAGG - K(Biotin)
Size 1 mg
Catalog # AS-65269-1
US$ $435
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is histone H3 (1-21) with symmetrical dimethylation at Arg2 and dimethylation at Lys4, followed by a C-terminal GGK with biotinylation on the side chain of Lys. Dimethylation of the guanidinium group of Arg2 is associated with transcriptional silencing. Set1 methyltransferase catalyzes dimethylation of Lys4, which has been associated with inactive and active euchromatic genes. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Storage -20C
References Musselman, CA and TG. Kutateladze Mol Interv 9, 314 (2010); Kirmizis, A. et al. Nat Struct Mol Biol 16, 449 (2009); Bernstein, B. et al. Proc Natl Acad Sci USA 99, 8695 (2002); Santos-Rosa, H. et al. Nature 419, 407 (2002).
Molecular Weight 2779.2
Sequence
(One-Letter Code)
A-R(Me2s)-T-K(Me2)-QTARKSTGGKAPRKQLAGG-K(Biotin)
Sequence
(Three-Letter Code)
H - Ala - Arg(Me2s) - Thr - Lys(Me2) - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Gly - Gly - Lys(Biotin) - OH
     
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