Login
Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Password:
Stay Logged In


Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Peptides  >  Histones  >  Histone H3 Peptides  >>  [Cit2, pThr3]-Histone H3 (1-21)-GGK(Biotin)

Product Name [Cit2, pThr3] - Histone H3 (1 - 21) - GGK(Biotin)
A - Cit - pT - KQTARKSTGGKAPRKQLAGG - K(Biotin)
Size 0.25 mg
Catalog # 65272-025
US$ $143
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is histone H3 (1-21) with deimination at Arg2 and phosphorylation at Thr3 followed by a C-terminal GGK linker with biotinylation on the side chain of this Lys. Arg2 is deiminated by peptidyl arginine deiminase 4 (PADI4). Conversion to citrulline (Cit) blocks methylation at this site and inhibits transcriptional activation. Phosphorylation of Thr3 begins in mitotic prophase and reverses in anaphase. This process is carried out by haspin in vitro. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Storage -20C
References Dai, J. et al. Gene Dev 19, 472 (2005); Cuthbert, G. et al. Cell 118, 545 (2004).
Molecular Weight 2804.2
Sequence
(One-Letter Code)
A-Cit-pT-KQTARKSTGGKAPRKQLAGG-K(Biotin)
Sequence
(Three-Letter Code)
H - Ala - Cit - pThr - Lys - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Gly - Gly - Lys(Biotin) - OH
     
  < Back