This peptide is histone H3 (21-44) with deimination at Arg26, converting it to Cit (citrulline). It is biotinylated through a C-terminal GGK linker. Deimination by peptidyl arginine deiminase 4 (PADI4) blocks methylation by the CARM1 methyltransferase and inhibits transcriptional activation. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Cuthbert, G. et al. Cell118, 545 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Thr - Lys - Ala - Ala - Cit - Lys - Ser - Ala - Pro - Ala - Thr - Gly - Gly - Val - Lys - Lys - Pro - His - Arg - Tyr - Arg - Pro - Gly - Gly - Gly - Lys(Biotin) - OH