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Peptides  >  Histones  >  Histone H3 Peptides  >>  [Lys(Me1)79]-Histone H3 (58-89)

Product Name [Lys(Me1)79] - Histone H3 (58 - 89)
TELLIRKLPFQRLVREIAQDF - K(Me1) - TDLRFQSAAI
Size 1 mg
Catalog # 65223-1
US$ $385
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is histone H3 58-89 with monomethylation at Lys79. Lys79 methylation is mediated by DOT1 protein. Hypermethylation at Lys79 is associated with active gene transcription while hypomethylation is associated with transcriptional silencing. Hypomethylation at Lys79 is associated with Sir1 silencing proteins, which further block methylation by DOT1.

Storage -20C
References Schubeler, D. et al. Gene Dev 18, 1263 (2004); Ng, H. et al. Proc Natl Acad Sci USA 100, 1820 (2003); Feng, Q. et al. Curr Biol 12, 1052 (2002).
Molecular Weight 3831.5
Sequence
(One-Letter Code)
TELLIRKLPFQRLVREIAQDF-K(Me1)-TDLRFQSAAI
Sequence
(Three-Letter Code)
H - Thr - Glu - Leu - Leu - Ile - Arg - Lys - Leu - Pro - Phe - Gln - Arg - Leu - Val - Arg - Glu - Ile - Ala - Gln - Asp - Phe - Lys(Me1) - Thr - Asp - Leu - Arg - Phe - Gln - Ser - Ala - Ala - Ile - OH
     
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