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Peptides  >  Histones  >  Histone H3 Peptides  >>  [Lys(Me2)79]-Histone H3 (58-89)-GGK(Biotin)

Product Name [Lys(Me2)79] - Histone H3 (58 - 89) - GGK(Biotin)
TELLIRKLPFQRLVREIAQDF - K(Me2) - TDLRFQSAAIGG - K(Biotin)
Size 0.25 mg
Catalog # AS-65228-025
US$ $149
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is histone H3 58-89 with dimethylation at Lys79 and biotin-labeled through a C-terminal GGK linker. Lys79 methylation is mediated by DOT1 protein. It has been shown that dimethylation at Lys79 is important for transcriptional activation via mixed lineage leukemia gene (MLL)-ENL-ER and MLL-AF9. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Storage -20C
References Milne, T. et al. Cancer Res 65, 11367 (2005); Schubeler, D. et al. Gene Dev 18, 1263 (2004); Feng, Q. et al. Curr Biol 12, 1052 (2002).
Molecular Weight 4314.1
Sequence
(One-Letter Code)
TELLIRKLPFQRLVREIAQDF-K(Me2)-TDLRFQSAAIGG-K(Biotin)
Sequence
(Three-Letter Code)
H - Thr - Glu - Leu - Leu - Ile - Arg - Lys - Leu - Pro - Phe - Gln - Arg - Leu - Val - Arg - Glu - Ile - Ala - Gln - Asp - Phe - Lys(Me2) - Thr - Asp - Leu - Arg - Phe - Gln - Ser - Ala - Ala - Ile - Gly - Gly - Lys(Biotin) - OH
     
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