This peptide is histone H4 (1-25) with acetylation at Lys12. It is biotinylated through a C-terminal GSGSK linker. Lys12 acetylation is necessary for the methylation of Lys9 of histone H3 in the formation of heterochromatin. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Swaminathan, J. et al. Gene Dev19, 65 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys(Ac) - Gly - Gly - Ala - Lys - Arg - His - Arg - Lys - Val - Leu - Arg - Asp - Asn - Gly - Ser - Gly - Ser - Lys(Biotin) - OH