This is human tumor suppressor protein p53 (368-393) monomethylated at Lys373 and biotinylated through a KGW linker at its N-terminus. Methylation at Lys373 is catalyzed by G9a and Glp lysine methyltransferases and is associated with inactive p53.
Krishnan, S. et al. ChemBioChem12, 254 (2011); Huang, J. et al. J Biol Chem285, 9636 (2010).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Biotin - Lys - Gly - Trp - His - Leu - Lys - Ser - Lys(Me1) - Lys - Gly - Gln - Ser - Thr - Ser - Arg - His - Lys - Lys - Leu - Met - Phe - Lys - Thr - Glu - Gly - Pro - Asp - Ser - Asp - NH2