p53K370Me2 is derived from amino acid residues 361-380 of human p53 tumor suppressor protein, with dimethylation at Lys370. This peptide promotes p53 interactions with both p21gene promoters and p53 binding protein 1 (53BP1), activating transcription of p53 target genes.
Egorova, K. Biochem75, 535 (2010).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Ser - Arg - Ala - His - Ser - Ser - His - Leu - Lys(Me2) - Ser - Lys - Lys - Gly - Gln - Ser - Thr - Ser - Arg - His - OH