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Peptides  >  Histones  >  Histone H4 Peptides  >>  [Lys(Ac)12/16]-Histone H4(1-25)-GSGSK(Biotin); H4K12/16(Ac), biotin-labeled

Product Name [Lys(Ac)12/16] - Histone H4(1 - 25) - GSGSK(Biotin); H4K12/16(Ac), biotin - labeled
SGRGKGGKGLG - K(Ac) - GGA - K(Ac) - RHRKVLRDNGSGS - K(Biotin)
Size 0.25 mg
Catalog # 65222-025
US$ $120
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is histone H4 (1-25) with acetylation at Lys12 and Lys16. It is biotinylated through a C-terminal GSGSK linker. It has been shown that human histone H4 is preferentially acetylated first at Lys16, then at Lys12. Diacetylated histone H4 has been shown to bind repressor protein TUP1. Acetylation of histone H4 also regulates heterochromatin formation by promoting the binding of bromodomains to p300 and transcription factor TAFII250 and inhibiting interactions with SIR3. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Storage -20C
References Carmen, A. et al. J Biol Chem 277, 4778 (2002); Turner, B. et al. FEBS Lett 252, 141 (1989).
Molecular Weight 3316.8
Sequence
(One-Letter Code)
SGRGKGGKGLG-K(Ac)-GGA-K(Ac)-RHRKVLRDNGSGS-K(Biotin)
Sequence
(Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys(Ac) - Gly - Gly - Ala - Lys(Ac) - Arg - His - Arg - Lys - Val - Leu - Arg - Asp - Asn - Gly - Ser - Gly - Ser - Lys(Biotin) - OH
     
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