This is histone H3 (1-21) symmetrically dimethylated at Arg8 with a methyl group added to each nitrogen of the guanidinium group. This peptide is biotinylated at the epsilon side chain of an additional C-terminal Lys. Methylation at Arg8 blocks G9a methylation of Lys9. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Rathert, P. et al. Nat Chem Biol4, 344 (2008).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg(Me2s) - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Lys(Biotin) - OH