This is histone H3 (23-34) trimethylated at Lys27 and biotinylated on the C-terminus through a GGK linker. Trimethylation of Lys27 promotes Polycomb protein (Pc)-chromatin association. This modification has also been shown to be associated with methylated CpG island genes in cancer cells. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Schlesinger, Y. et al. Nat Genet39, 232 (2007); Zhang, X. et al. Nat Struct Mol Biol14, 869 (2007); Min, J. et al. Genes Dev17, 1823 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Lys - Ala - Ala - Arg - Lys(Me3) - Ser - Ala - Pro - Ala - Thr - Gly - Gly - Gly - Gly - Lys(Biotin) - OH