This peptide is histone H3 (44-63) with acetylation at Lys56. Lys56 acetylation occurs during premeiotic and mitotic S phases and persists through DNA damage repair and is catalyzed by the Rtt109-Vps75 histone acetyltransferase (HAT) complex. A deficiency of acetylated Lys56 in histone H3 is implicated in spontaneous chromosome breaks during mitosis, suggesting that this modification is important for replisome integrity and DNA replication.
Han, J. et al. J Biol Chem282, 28587 (2007); Schneider, J. et al. J Biol Chem281, 37270 (2006).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Thr - Val - Ala - Leu - Arg - Glu - Ile - Arg - Arg - Tyr - Gln - Lys(Ac) - Ser - Thr - Glu - Leu - Leu - Ile - Arg - OH