This peptide is histone H3 (44-63) with acetylation at Lys56. Lys56 acetylation occurs during premeiotic and mitotic S phases and persists through DNA damage repair and is catalyzed by the Rtt109-Vps75 histone acetyltransferase (HAT) complex. A deficiency of acetylated Lys56 in histone H3 is implicated in spontaneous chromosome breaks during mitosis, suggesting that this modification is important for replisome integrity and DNA replication.
Storage
-20°C
References
Han, J. et al. J Biol Chem282, 28587 (2007); Schneider, J. et al. J Biol Chem281, 37270 (2006).
Molecular Weight
2444.9
Sequence (One-Letter Code)
GTVALREIRRYQ-K(Ac)-STELLIR
Sequence (Three-Letter Code)
H - Gly - Thr - Val - Ala - Leu - Arg - Glu - Ile - Arg - Arg - Tyr - Gln - Lys(Ac) - Ser - Thr - Glu - Leu - Leu - Ile - Arg - OH
