This is histone H3 (21-44) trimethylated at Lys27 with an additional C-terminal Lys and biotinylation on the epsilon side chain of this Lys. Trimethylation of Lys27 promotes Polycomb protein (Pc)-chromatin association and is associated with heterochromatin assembly and gene silencing. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Zhang, X. et al. Nat Struct Mol Biol14, 869 (2007); Min, J. et al. Genes Dev17, 1823 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Thr - Lys - Ala - Ala - Arg - Lys(Me3) - Ser - Ala - Pro - Ala - Thr - Gly - Gly - Val - Lys - Lys - Pro - His - Arg - Tyr - Arg - Pro - Gly - Lys(Biotin) - OH