This is histone H3 (23-31). Lys27 within this sequence is methylated by the polycomb group protein EZH2. Overexpression of EXH2 is associated with several human cancer lines, such as prostate and breast cancer.
Kuzmichev, A. et al. Mol Cell14, 183 (2004); Kleer, C. et al. Proc Natl Acad Sci USA100, 11606 (2003); Varambally, S. et al. Nature419, 624 (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Lys - Ala - Ala - Arg - Lys - Ser - Ala - Pro - Ala - OH