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Peptides  >  Histones  >  Histone H3 Peptides  >>  [Arg(Me2a)26]-Histone H3 (15-36)-GGK(Biotin), H3R26(Me2a), biotin labeled

Product Name [Arg(Me2a)26] - Histone H3 (15 - 36) - GGK(Biotin), H3R26(Me2a), biotin labeled
APRKQLATKAA - R(Me2a) - KSAPATGGVKGG - K(Biotin)
Size 1 mg
Catalog # AS-65261-1
US$ $350
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is histone H3 (15-36) asymmetrically dimethylated at Arg26, followed by a C-terminal GGK with biotinylation on the side chain of Lys. Dimethylation at Arg26 is catalyzed by CARM1 and inhibits deimination by peptidylarginine deiminase (PADI)-4. Arginine methylation of histone H3 is associated with transcriptional activation. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Storage -20C
References Cuthbert, G. et al. Cell 118, 545 (2004).
Molecular Weight 2704.2
Sequence
(One-Letter Code)
APRKQLATKAA-R(Me2a)-KSAPATGGVKGG-K(Biotin)
Sequence
(Three-Letter Code)
H - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Thr - Lys - Ala - Ala - Arg(Me2a) - Lys - Ser - Ala - Pro - Ala - Thr - Gly - Gly - Val - Lys - Gly - Gly - Lys(Biotin) - OH
Product Citations Mann, M. et al. (2013). PELP1 oncogenic functions involve CARM1 regulation. Carcinogenesis 34, 1468. doi: 10.1093/carcin/bgt091.
     
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