Des - gamma - carboxylated Osteocalcin/Bone Gla Protein
Size
0.25 mg
Catalog #
65307-025
US$
$175
Purity
% Peak Area By HPLC ≥ 95%
Description
This peptide is des-gamma-carboxylated osteocalcin/bone Gla protein (BGP). Osteocalcin/BGP is the most abundant non-collagenous protein of the bone extracellular matrix and is secreted by osteoblasts. This des-gamma-carboxylated peptide serves as a substrate for vitamin K-dependent carboxylase, which modifies Glu17, Glu21, and Glu24 to Gla residues.
Storage
-20°C
References
Houben, R. et al. Biochem J364, 323 (2002); Ducy, P. et al. Nature382, 448 (1996); Benton, ME. et al. Biochem37, 13262 (1995); Engelke, J. et al. Biochim Biophys Acta1078, 31 (1991); Ulrich, M. et al. Biochim Biophys Acta830, 105 (1985).
H - Tyr - Leu - Tyr - Gln - Trp - Leu - Gly - Ala - Pro - Val - Pro - Tyr - Pro - Asp - Pro - Leu - Glu - Pro - Arg - Arg - Glu - Val - Cys - Glu - Leu - Asn - Pro - Asp - Cys - Asp - Glu - Leu - Ala - Asp - His - Ile - Gly - Phe - Gln - Glu - Ala - Tyr - Arg - Arg - Phe - Tyr - Gly - Pro - Val - OH (Disulfide bridge:C23 - 29)
